We implement extensive research of the immediate and long-term brain damage induced by nerve agents and other toxic compounds. Based on the characterization of the immediate and long term injury, we evaluate the potential pharmacological treatments
administered either prophylactically or at various time post-exposure, to eliminate or minimize brain pathology. Methods include:
Biochemical and molecular analysis of neuronal enzyme activity, inflammatory markers in neurons and glia, cytokines and more.
Evaluation of tissue damage through histology, histochemistry and immune-
Receptor density (Bmax) and affinity (KD) evaluation.
Continuous tethered electroencephalography (EEG) and telemetry
Microdialysis of neurotransmitters
Immunofluorescence labeling of neurons and glial populations in the rat brain
Electrocardiogram and blood pressure evaluation in rodents
Non-invasive, repeated follow-up of core temperature in males and females rats
Histology and pathology
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