​​Neurological insults

We implement extensive research of the immediate and long-term brain damage induced by nerve agents and other toxic compounds. Based on the characterization of the immediate and long term injury, we evaluate the potential pharmacological treatments ​

administered either prophylactically or at various time post-exposure, to eliminate or minimize brain pathology. Methods include:

• Biochemical and molecular analysis of neuronal enzyme activity, inflammatory markers in neurons and glia, cytokines and more. 
  

• Evaluation of tissue damage through histology, histochemistry and immune- 
  

• Histochemistry. 
  

• Receptor density (Bmax) and affinity (KD) evaluation.
  

• Continuous tethered electroencephalography (EEG)  and telemetry
  

• Microdialysis of neurotransmitters
  

• Behavioral tests
  

Immunofluorescence labeling of neurons and glial populations in the rat brain