Design of biologically active molecules, based on computerized modeling and subsequent prioritization. Testing and pharmacological evaluation of these molecules, both in vitro and in vivo, using a vast variety of animal models.
Rivastigmine, a reversible cholinesterase inhibitor, approved in the US and EU for the treatment of dementia due to Alzheimer’s disease or Parkinson’s disease, was suggested as pretreatment against nerve agent poisoning.
The tissue culture facility has been studying the beneficial effect of stem cell implantation following ocular injury. To that end, limbal stem cells are isolated from corneal biopsies, cultivated and characterized.
The organic chemistry department uses computational methods such as ab-initio quantum-mechanical calculations, which are routinely employed for elucidation of reaction mechanisms, development of novel synthetic
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