Ever since Edward Jenner’s vaccine for smallpox, vaccines have revolutionized preventative medicine. The IIBR is leading an effort in the development of vaccines against select agents. Vaccine development is carried out in three main approaches:
IIBR scientists are designing novel strategies for prophylactics of life-threatening infectious diseases caused by lethal bacterial pathogens such as Bacillus anthracis, Yersinia pestis and Francisella tularensis, which are developed on the basis of extensive studies addressing mechanisms of virulence manifestation.
Cell-free vaccines are considered safe and effective. The tripartite toxins of Bacillus anthracis are essential for the development of Anthrax, therefore can serve as excellent candidates for a protein vaccine.
Most currently-available vaccines were empirically designed, and contain attenuated or killed pathogens. The need to cultivate infectious agents and isolate the inactivated whole pathogen or some of its purified components, as well as concerns of safety, rendered this approach elusive for many pathogens.
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